Related Experiment Video

Updated: Feb 4, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.7K

Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: A systematic

Gianluca Ianiro1, Marcello Maida2, Johan Burisch3

  • 1Gastroenterology Area, Fondazione Policlinico Universitario Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

United European Gastroenterology Journal
|October 6, 2018
PubMed
Abstract

Insights

Multiple fecal microbiota transplantation (FMT) infusions significantly increase treatment success rates for recurrent Clostridium difficile infection (rCDI). Optimizing FMT protocols, considering routes and dosage, is crucial for better clinical outcomes.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiome Research

Background:

  • Recurrent Clostridium difficile infection (rCDI) presents a significant clinical challenge.
  • Current treatment protocols for rCDI using fecal microbiota transplantation (FMT) lack standardization.
  • Optimizing FMT protocols is essential for improving patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of different fecal microbiota transplantation (FMT) protocols for treating recurrent Clostridium difficile infection (rCDI).
  • To assess the impact of various FMT parameters, including routes of administration, number of infusions, and infused material, on treatment success rates.
  • To identify factors that can optimize FMT protocols for rCDI in clinical practice.

Main Methods:

  • A systematic literature search was conducted across major databases (MEDLINE, Embase, SCOPUS, Web of Science, Cochrane Library) up to May 2017.
  • Studies involving multiple FMT infusions for patients with rCDI who did not respond to a single infusion were included.
  • Data from fifteen studies, encompassing 1150 subjects, were analyzed using random effects meta-analysis.

Main Results:

  • Multiple FMT infusions significantly increased overall efficacy rates for rCDI (76% single vs. 93% multiple infusions).
  • Efficacy varied by route: duodenal delivery (73% vs. 81%) and capsule (80% vs. 92%) showed improvement with multiple infusions, while colonoscopy (78% vs. 98%) and enema (56% vs. 92%) demonstrated substantial gains.
  • Lower efficacy was associated with smaller fecal amounts (≤50g) and enema administration after a single infusion. Route of delivery (duodenal vs. colonoscopy) also impacted overall efficacy.

Conclusions:

  • The route of administration, number of infusions, and fecal dosage are critical factors influencing the efficacy of FMT for rCDI.
  • Multiple infusions demonstrate a clear benefit in improving treatment success rates for rCDI.
  • These findings provide valuable insights for refining and optimizing FMT protocols in clinical settings to enhance patient care for recurrent C. difficile infections.
Keywords:
Clostridium difficilefaecal microbiota transplantationfaecal transplantmeta-analysissystematic review

More Related Videos

Murine Fecal Isolation and Microbiota Transplantation07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

5.6K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.4K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.4K
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
230
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.1K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.3K