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Adherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and

Nathan Ford1, Roz Scourse2, Maud Lemoine3

  • 1Department of HIV and Global Hepatitis Program World Health Organization Geneva Switzerland.

Hepatology Communications
|October 6, 2018
PubMed

Insights

High adherence to hepatitis B virus (HBV) antiviral therapy is crucial for successful treatment outcomes. A meta-analysis of 30 studies found overall patient adherence to be 74.6%.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Chronic hepatitis B virus (HBV) infection requires long-term antiviral therapy.
  • Patient adherence to treatment is essential for achieving successful outcomes and preventing disease progression.

Purpose of the Study:

  • To determine the overall proportion of patients adherent to HBV antiviral therapy.
  • To identify barriers to treatment adherence in chronic HBV infection.

Main Methods:

  • A systematic literature search was conducted across three databases and two conference abstract collections up to January 2018.
  • Data from 30 studies, including 23,823 patients, were pooled using random effects meta-analysis to calculate adherence rates.

Main Results:

  • The overall adherence rate to HBV antiviral therapy was 74.6% (95% CI, 67.1%-82.1%).
  • Adherence rates were comparable between high-income settings (75.1%) and low- and middle-income settings (72.9%).
  • Key barriers to adherence included forgetting medication, misunderstanding its importance, and disruptions to daily routines.

Conclusions:

  • Regular assessment and reporting of treatment adherence should be integrated into routine chronic HBV care.
  • Further research is needed to evaluate the effectiveness of evidence-based interventions, proven for HIV and other chronic diseases, in improving HBV treatment adherence.

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