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TAK1 mediates convergence of cellular signals for death and survival

Sabreena Aashaq1, Asiya Batool2, Khurshid I Andrabi2

  • 1Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, 190006, India. mirsabreena.scholar@kashmiruniversity.net.

Apoptosis : an International Journal on Programmed Cell Death
|October 6, 2018
PubMed

Insights

TGF-β activated kinase 1 (TAK1) regulates cell survival and death through complex signaling pathways. It also influences energy balance and cell fate via AMPK and mTORC1.

Area of Science:

  • Cellular Biology
  • Molecular Signaling
  • Biochemistry

Background:

  • TGF-β activated kinase 1 (TAK1) is a serine/threonine kinase involved in numerous cellular processes.
  • TAK1 interacts with TAB1, TAB2, and TAB3, forming a complex regulatory network.
  • TAK1 signaling crosstalks with major pathways like JNK, p38 MAPK, and IKK.

Purpose of the Study:

  • To review the multifaceted roles of TAK1 in cellular regulation.
  • To elucidate TAK1's involvement in cell death and survival pathways.
  • To highlight TAK1's function in energy homeostasis and its connection to mTORC1.

Main Methods:

  • Literature review of studies on TAK1 signaling.
  • Analysis of TAK1's interactions with binding partners (TAB1-3).
  • Examination of TAK1's crosstalk with JNK, p38 MAPK, IKK, AMPK, and mTORC1 pathways.

Main Results:

  • TAK1 regulates embryonic development, differentiation, autophagy, apoptosis, and cell survival.
  • TAK1's complex regulation involves significant crosstalk with key signaling cascades.
  • TAK1 plays a role in energy homeostasis via AMPK and influences mTORC1.

Conclusions:

  • TAK1 is a critical regulator of cellular fate, integrating diverse signaling inputs.
  • TAK1's role extends to metabolic control, impacting cell survival decisions.
  • Understanding TAK1 signaling is crucial for comprehending cellular responses to stress and metabolic cues.
Keywords:
ApoptosisAutophagyCytokineInflammatorySmad

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