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Updated: Feb 4, 2026
07:16
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
14.6K
Phase II Trial of Acai Juice Product in Biochemically Recurrent Prostate Cancer
Elizabeth R Kessler1, Lih-Jen Su1, Dexiang Gao1
11 University of Colorado, Aurora, CO, USA.
Integrative Cancer Therapies
|October 6, 2018
Summary
Acai berry juice did not meet its primary endpoint for prostate cancer treatment but showed promise in stabilizing prostate-specific antigen (PSA) levels in 71% of patients, suggesting further research potential.
Area of Science:
- Oncology
- Phytochemistry
- Clinical Trials
Background:
- Plant derivatives are explored for prostate cancer therapy due to anti-inflammatory and antioxidant properties.
- Acai berry, rich in phytochemicals, may inhibit prostate cancer growth.
Purpose of the Study:
- To evaluate the efficacy of Acai berry Juice Product in patients with biochemically recurrent prostate cancer.
- To assess prostate-specific antigen (PSA) response as the primary endpoint.
Main Methods:
- A phase II, Simon 2-stage clinical trial was conducted.
- Patients with rising PSA (≥0.2 ng/mL) received Acai Juice Product twice daily.
- Treatment continued until PSA progression.
Main Results:
- The study did not achieve the primary endpoint of a 50% PSA response.
- PSA doubling time was extended in 71% of patients (95% CI: 48%–89%).
- Sustained PSA response was observed in a small subset of patients.
Conclusions:
- Acai berry Juice Product did not meet the primary efficacy endpoint.
- The product demonstrated good tolerability and potential for PSA stabilization in recurrent prostate cancer.
- Further investigation is warranted in this patient population.
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