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Updated: Feb 4, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Effects of anti-diabetic drugs on bone metabolism
Guillaume Mabilleau1,2, Daniel Chappard1,2, Peter R Flatt3
1a 1 GEROM-LHEA, Institut de Biologie en Santé, LUNAM Université, Angers, France.
Abstract:
An increased fracture risk is observed in Type 1 and Type 2 diabetic patients. Although diabetes-related complications are important in the etiology of bone fracture in diabetes, the effect of anti-diabetic medications should not be neglected. Indeed, many drugs used commonly to treat diabetes can interfere with bone physiology, resulting in a positive or negative impact on skeletal health. The aim of the present review is to summarize the current evidence on the effects of anti-diabetic drugs on bone.
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