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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

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Beta-lactam-induced severe neutropaenia: a descriptive study.

Thierry Vial¹, Henry Bailly¹, Marie-Christine Perault-Pochat²

¹Centre Régional de Pharmacovigilance, Hospices Civils de Lyon, Service Hospitalo-Universitaire de Pharmacotoxicologie, 162 avenue Lacassagne, Lyon, 69424, France.

Fundamental & Clinical Pharmacology

|October 6, 2018

Summary

Beta-lactam-induced severe neutropaenia is rare, typically occurring after prolonged treatment. Most patients recover after drug discontinuation, and subsequent beta-lactam use is usually safe.

Keywords:

adverse drug reaction beta-lactam neutropaenia severity

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Published on: November 4, 2010

Area of Science:

Pharmacovigilance
Hematology
Internal Medicine

Background:

Severe neutropaenia is a serious adverse drug reaction.
Beta-lactam antibiotics are commonly prescribed, increasing the potential for associated toxicity.

Purpose of the Study:

To characterize beta-lactam-induced severe neutropaenia.
To assess recurrence risk upon re-exposure to beta-lactams.

Main Methods:

Analysis of French Pharmacovigilance Database reports from 2010.
Inclusion of 62 cases of agranulocytosis linked to beta-lactam exposure.
Exclusion of cases with alternative causes or attributable to other drugs.

Main Results:

Median patient age was 65 years, with neutropaenia occurring after a median of 16 days of treatment.
Most patients (47%) were diagnosed via routine blood counts; median neutrophil nadir was 0.125 × 10^9/L.
Recovery occurred within 2-56 days after beta-lactam cessation; severe sepsis occurred in 3 patients, with one fatality.

Conclusions:

Beta-lactam-induced agranulocytosis is uncommon, often linked to prolonged therapy, with generally favorable outcomes.
Recurrence of neutropaenia after subsequent beta-lactam administration is infrequent, with most patients tolerating re-exposure well.