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Porcine As a Training Module for Head and Neck Microvascular Reconstruction
Published on: September 29, 2018
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Adaptive radiotherapy for head and neck cancer
J Castelli1,2,3, A Simon2,3, C Lafond1,2,3
1a Radiotherapy Department , Centre Eugene Marquis , Rennes , France.
Acta Oncologica (Stockholm, Sweden)
|October 6, 2018
Summary
Adaptive radiotherapy (ART) corrects anatomical variations during head and neck cancer (HNC) treatment. ART optimizes radiation dose delivery, potentially reducing toxicity and improving local control, but requires further randomized trials.
Area of Science:
- Radiation Oncology
- Medical Physics
- Oncology
Background:
- Anatomical variations during head and neck cancer (HNC) intensity-modulated radiotherapy (IMRT) can cause dose deviations.
- Adaptive radiotherapy (ART) addresses these variations through replanning to optimize dose distribution.
- This review focuses on ART strategies and benefits in HNC treatment.
Purpose of the Study:
- Identify ART strategies for HNC.
- Estimate the dosimetric benefits of ART.
- Evaluate the clinical benefits of ART.
Main Methods:
- Systematic electronic literature search (PubMed/MEDLINE, Science Direct, 2005-2016).
- Included 29 articles from 134 assessed for eligibility.
- Compared studies with and without ART, focusing on dosimetric and clinical outcomes.
Main Results:
- ART replanning, ideally early in treatment, reduces parotid gland and spinal cord doses.
- ART improves target coverage and homogeneity compared to standard IMRT.
- Clinical data suggests ART may decrease xerostomia, improve quality of life, and enhance local control, particularly for patients with significant variations.
Conclusions:
- Adaptive radiotherapy shows promise in reducing toxicity and improving local control for locally advanced HNC.
- Further randomized trials are needed to confirm ART benefits for routine clinical practice.
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