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Suppressing inflammation and enhancing osteogenesis using novel CS-EC@Ca microcapsules.

Xiaoman Li1, Bing Han1, Xiaoyan Wang1

  • 1Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

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|October 6, 2018
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Chitosan-coated calcium hydroxide microcapsules significantly reduced inflammation and promoted bone growth in rabbits. These findings suggest potential for treating inflammatory bone destruction, such as in apical periodontitis.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Inflammatory bone destruction poses challenges in regenerative medicine.
  • Calcium hydroxide is used in bone repair, but its efficacy can be limited.
  • Developing effective delivery systems for bone regeneration is crucial.

Purpose of the Study:

  • To evaluate chitosan-coated calcium hydroxide-loaded microcapsules (CS-EC@Ca microcapsules) for in vivo inflammation suppression and osteogenesis enhancement.
  • To compare the effects of CS-EC@Ca microcapsules with calcium hydroxide (Ca(OH)2) and Bio-oss in a rabbit mandibular defect model.

Main Methods:

  • Mandibular bone defects in rabbits were created and treated with Ca(OH)2, Bio-oss, or CS-EC@Ca microcapsules.
  • Inflammation was induced daily with lipopolysaccharides for 7 days.
  • Bone regeneration and inflammation markers were assessed at 4 and 12 weeks using micro-CT, histology, and real-time PCR.

Main Results:

  • CS-EC@Ca microcapsules and Bio-oss promoted significant nascent bone formation compared to controls.
  • The Ca(OH)2 group showed slower recovery than controls.
  • Osteocalcin and collagen type I expression increased significantly in microcapsule and Bio-oss groups versus control and Ca(OH)2 groups.
  • CS-EC@Ca microcapsules demonstrated the most significant reduction in inflammatory factors (IL-6, TNF-α) mRNA levels.

Conclusions:

  • CS-EC@Ca microcapsules effectively suppressed inflammation and enhanced osteogenesis in a rabbit model.
  • These microcapsules show promise for treating inflammatory bone destruction conditions like apical periodontitis.