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Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux
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[Diurnal rhythm of arterial pressure in patients with acromegaly]

Yu V Zav’yalova, N N Borovkov, P A Dulin

    Klinicheskaia Meditsina
    |October 6, 2018
    PubMed

    Insights

    Patients with active acromegaly experience significant arterial hypertension, including abnormal nocturnal blood pressure patterns. This study highlights the prevalence of non-dipper profiles and elevated nocturnal blood pressure in acromegaly patients.

    Area of Science:

    • Endocrinology
    • Cardiovascular Medicine
    • Hypertension Research

    Background:

    • Acromegaly is associated with cardiovascular complications.
    • Arterial hypertension is a known comorbidity in acromegaly.

    Purpose of the Study:

    • To investigate the 24-hour arterial pressure (AP) profile in patients with active acromegaly.
    • To assess the prevalence of abnormal diurnal blood pressure patterns in this population.

    Main Methods:

    • 24-hour ambulatory arterial pressure monitoring was conducted.
    • 46 patients in the active phase of acromegaly were included.
    • Analysis focused on diurnal variations, nocturnal fall, and nocturnal AP levels.

    Main Results:

    • Systolic-diastolic arterial hypertension was detected in the majority of patients.
    • A significant absence of the normal nocturnal fall in AP (non-dipper profile) was observed.
    • An increased number of patients exhibited elevated nocturnal AP (night-peakers).

    Conclusions:

    • Active acromegaly is characterized by significant arterial hypertension.
    • Abnormal diurnal arterial pressure patterns, specifically the non-dipper profile and night-peaking, are common in acromegaly.
    • These findings underscore the importance of continuous blood pressure monitoring in acromegaly management.

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