International experiences with ofloxacin, a new quinolone

In vitro and in vivo antibacterial activities of ofloxacin, a new quinolone, are presented. Ofloxacin was found to be characterized by potent bactericidal activity due to its strong inhibition of bacterial DNA gyrase. The high antibacterial activity of ofloxacin in vivo was discussed with respect to its physiochemical properties, i.e., hydrophobicity and bioavailability including high serum concentrations and easy entry into bacterial cells.