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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

32.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.5K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.1K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
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What is Missing for Stem Cell-Based Therapies in Dentistry.

George T J Huang, Franklin Garcia-Godoy

    The Journal of the Tennessee Dental Association
    |October 6, 2018
    PubMed
    Summary

    Regenerative dentistry shows promise in animal studies for repairing dental tissues using stem cells. Clinical application requires specialized Good Manufacturing Practice facilities, which are currently scarce.

    Area of Science:

    • Regenerative Dentistry
    • Dental Stem Cell Therapy
    • Tissue Engineering

    Background:

    • Significant advancements in regenerative dentistry have been observed in large animal models.
    • Applications include regeneration of pulp tissue in endodontics and periodontal tissues in periodontics.

    Purpose of the Study:

    • To highlight the potential of dental stem cells in regenerating dental tissues.
    • To underscore the need for specialized facilities for clinical translation.

    Main Methods:

    • Utilizing dental stem cells for tissue regeneration.
    • Demonstrating efficacy in large animal studies for endodontic and periodontal applications.

    Main Results:

    • Successful regeneration of pulp tissues within empty root canals.

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  • Regeneration of periodontal pockets to a normal state.

    • Conclusions:

    • Dental stem cell therapy shows significant potential for clinical application in regenerative dentistry.
    • The establishment of Good Manufacturing Practice facilities is crucial for processing stem cells for patient care but remains a significant challenge due to their rarity.