Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
RNA Splicing01:32

RNA Splicing

60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.9K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.9K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.6K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.6K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

13.3K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drivers of Efficiency Breakthroughs: Key Technological Advances in Monolithic Perovskite/Silicon Tandem Solar Cells.

Nanomaterials (Basel, Switzerland)·2026
Same author

Collective exerkines mediate physical activity mitigating new-onset heart failure risk in older adults with prediabetes or diabetes: a community-based longitudinal cohort study.

Cardiovascular diabetology·2026
Same author

Perovskite/Silicon Tandem Solar Cells With Stabilized Grain Boundaries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Safflower Polysaccharides Alleviate TNBS-Induced Colitis by Modulating Gut Immunity.

Foods (Basel, Switzerland)·2025
Same author

Preparation and properties of safflower seed oil and keratinocyte growth factor-2 assembled nanoemulsion gel.

International journal of biological macromolecules·2025
Same author

Revealing Serotonin Derivatives in Safflower Seed Meal as Potential Anti-Ulcerative Colitis Drugs: In Vitro and Computational Evidence.

Molecules (Basel, Switzerland)·2025
Same journal

Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

CRISPR-Cas12a-based liquid biopsy technology: challenges in large-scale clinical application.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Diagnostic biomarkers, prognostic signatures, and therapeutic resistance: shedding light on the dual role of autophagy in glioblastoma.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Artificial intelligence in diagnostic software: validation, safety, and lifecycle challenges in Europe.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Strategies for effective occurrence Management in Resource-Limited Clinical Laboratories: Challenges and practical solutions.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.3K

Long non-coding RNA HOXD-AS1 in cancer.

Lianlian Li1, Yong Wang2, Xiaoyu Zhang1

  • 1Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 6, 2018
PubMed
Summary
This summary is machine-generated.

Long non-coding RNA HOXD-AS1 plays a key role in various cancers. Aberrant HOXD-AS1 expression correlates with clinical features and impacts tumor progression, suggesting its potential as a cancer biomarker and therapeutic target.

Keywords:
BiomarkerDiagnosisHOXD-AS1LncRNAPrognosisTherapeutic target

More Related Videos

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K
Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Related Experiment Videos

Last Updated: Feb 4, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.3K
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K
Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are implicated in tumorigenesis and cancer progression.
  • The HOXD-AS1 gene, located in the HOXD cluster, is increasingly recognized for its role in various cancers.

Purpose of the Study:

  • To review the biological functions and mechanisms of HOXD-AS1 in human cancers.
  • To explore HOXD-AS1's potential as a diagnostic/prognostic biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on HOXD-AS1 in human cancers.
  • Analysis of HOXD-AS1 expression patterns and their correlation with clinical features.
  • Investigation of HOXD-AS1's regulatory mechanisms in tumor cell growth, invasion, and migration.

Main Results:

  • HOXD-AS1 is aberrantly expressed in multiple cancers, including bladder, cervical, colorectal, gastric, ovarian, prostate, glioma, hepatocellular carcinoma, melanoma, osteosarcoma, and non-small cell lung cancer.
  • Aberrant HOXD-AS1 expression is associated with patient clinical features.
  • HOXD-AS1 influences tumor cell growth, invasion, and migration through diverse molecular mechanisms.

Conclusions:

  • HOXD-AS1 is a significant factor in the development and progression of various human cancers.
  • HOXD-AS1 holds promise as a potential diagnostic/prognostic biomarker for cancer.
  • HOXD-AS1 represents a potential novel therapeutic target for cancer treatment.