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Human PAF complexes in endocrine tumors and pancreatic cancer

Shonali Deb1, Moorthy P Ponnusamy2, Shantibhusan Senapati3

  • 1a Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. sbatra@unmc.edu.

Expert Review of Endocrinology & Metabolism
|October 7, 2018
PubMed

Insights

The human RNA polymerase II-associated factor (hPAF) complex plays roles in transcription and cell cycle regulation. Its subunits are implicated in pancreatic and endocrine cancers, suggesting a role in tumor development.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The human RNA polymerase II-associated factor (hPAF) complex, comprising hPaf1, parafibromin, hLeo1, hCtr9, and hSki8, is conserved across species.
  • hPAF functions in transcription elongation, mRNA quality control, and cell cycle regulation, similar to its yeast counterpart (yPAF).

Purpose of the Study:

  • To review the role of the hPAF complex and its subunits in endocrine and pancreatic cancers.
  • To explore the functions and dysregulation of hPAF in cancer development.

Main Methods:

  • Literature review focusing on the hPAF complex and its subunits.
  • Analysis of existing research on hPAF's involvement in cancer biology.

Main Results:

  • hPaf1 subunit amplification and overexpression are observed in pancreatic cancer.
  • The parafibromin subunit is linked to hereditary hyperparathyroidism type 2 (HRPT-2) and tumor suppression.
  • Dysregulation of hPAF subunits is potentially involved in endocrine and other cancers.

Conclusions:

  • The hPAF complex and its subunits are critical in regulating cellular processes relevant to cancer.
  • Further investigation into hPAF's role could reveal new therapeutic targets for endocrine and pancreatic cancers.
Keywords:
PAF complexendocrine tumorhPaf1oncogenetranscriptiontumor-suppressor genewnt signaling

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