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Updated: Feb 4, 2026

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
Published on: March 12, 2020
Control of colon cancer development and progression by selected estrogen receptor modulators
Valentina Martineti1, Sandra Silvestri2, Francesco Tonelli3
1a Department of Internal Medicine, School of Medicine, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy. v.martineti@dmi.unifi.it.
Abstract:
Estrogens behave as protective agents on the development of colorectal cancer, and hormonal-replacement therapy is associated with an increased survival rate in women with this disease, indicating that estrogenic therapy correlates with a better prognosis. The protective effect of estrogens on Fcolorectal cancer development and progression is presumably related to the expression of estrogen receptors in colon mucosa, with the estrogen receptor-β isoform being the predominant one. This observation suggests that estrogen receptor-β could have an inhibitory effect on colorectal cancer cell proliferation and a regulatory effect on colonic mucosa cell growth, opening the discussion on a pharmacologic approach to colorectal cancer prevention and therapy based on estrogenic compounds.
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