Ion channels of primate ovarian endocrine cells: identification and functional significance

Ion channels are crucially involved in cellular functions, but little is known about molecular identity, subunit composition and the specific role of ion channels in ovarian endocrine cells in human and nonhuman primates. Using human luteinizing granulosa cells, a few groups have started to address these questions and have begun to show molecular identity of ion channels, electrophysiological functions and the relationship to hormone production, as well as regulation by hormones and intraovarian factors. Functional ion channels that have been identified so far include T- and L-type Ca²⁺ channels (Ca_v3.2, Ca_v1.2), a voltage-dependent Na⁺ channel (Na_v1.7), as well as voltage- (K_v4.2) and Ca²⁺-dependent K⁺ channels (BK_Ca). Since all these ion channels were found to be involved in steroid hormone synthesis and are expressed by endocrine ovarian cells in human and nonhuman ovary, it has been proposed that they are physiological key molecules for ovarian function. Furthermore, they may be novel targets for modulating ovarian functions.