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Clozapine treatment may cause stuttering, a side effect that appears dose-related. Reducing clozapine dosage significantly improved stuttering in two reported cases.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is an atypical antipsychotic medication used for treatment-resistant schizophrenia.
  • Adverse effects of clozapine are well-documented, but stuttering is not commonly reported.

Purpose of the Study:

  • To report two cases demonstrating a potential association between clozapine treatment and the onset of stuttering.
  • To investigate the dose-dependency of clozapine-induced stuttering.

Main Methods:

  • Case report analysis of two patients treated with clozapine.
  • Clinical observation of stuttering symptoms and response to clozapine dosage adjustments.

Main Results:

  • Both patients developed stuttering during clozapine therapy.
  • Stuttering severity was correlated with clozapine dosage.
  • Reduction in clozapine dose led to marked improvement in stuttering for both individuals.

Conclusions:

  • Clozapine may induce or exacerbate stuttering in a dose-dependent manner.
  • Monitoring for speech disturbances, including stuttering, is warranted in patients receiving clozapine.
  • Dosage adjustment of clozapine should be considered in cases of treatment-emergent stuttering.