Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Folding Quality Check in the RER

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

Lattice Centering and Coordination Number

Lattice Centering and Coordination Number

The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...

PD Controller: Design

PD Controller: Design

In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...

Positive Regulator Molecules

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

Center of Gravity

Center of Gravity

The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...

Center of Gravity

Center of Gravity

The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy·2026

Same author

IgA is necessary and sufficient to prevent norovirus infection in mice.

Science translational medicine·2026

Same author

Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen.

bioRxiv : the preprint server for biology·2026

Same author

Mixed Signals: T Cells as Architects of IgE Immunity.

Immunological reviews·2026

Same author

Extrafollicular and other non-germinal center B cell responses.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same author

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.

The Journal of experimental medicine·2026

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers

Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers

Published on: April 9, 2014

Checking into the germinal centers: PD-1 regulates entry.

Stephanie C Eisenbarth¹

¹Departments of Laboratory Medicine, Immunobiology, and Medicine, Yale University School of Medicine, New Haven, CT 06520 USA.

Science Immunology

|October 7, 2018

Summary

This summary is machine-generated.

Programmed cell death protein 1 (PD-1) regulates T follicular helper cell positioning within lymph node germinal centers. This finding is crucial for understanding immune responses and B cell development.

More Related Videos

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Related Experiment Videos

Last Updated: Feb 4, 2026

Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers

Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers

Published on: April 9, 2014

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Area of Science:

Immunology
Cell Biology
Lymphocyte Biology

Background:

T follicular helper (Tfh) cells are critical for adaptive immunity.
Germinal centers within lymph nodes are key sites for B cell maturation and antibody production.
The precise localization of Tfh cells within germinal centers influences immune response efficacy.

Purpose of the Study:

To investigate the role of Programmed cell death protein 1 (PD-1) in Tfh cell localization.
To determine how PD-1 signaling affects the spatial organization of Tfh cells within lymph node germinal centers.

Main Methods:

Utilized advanced imaging techniques to visualize Tfh cell behavior in lymph nodes.
Employed genetic manipulation to study the function of PD-1 in Tfh cells.
Analyzed Tfh cell migration patterns and interactions within the germinal center microenvironment.

Main Results:

PD-1 signaling was found to be a key regulator of Tfh cell positioning.
Tfh cells lacking PD-1 exhibited altered localization within germinal centers.
Specific PD-1-dependent mechanisms dictate Tfh cell entry and retention in distinct germinal center zones.

Conclusions:

Programmed cell death protein 1 (PD-1) plays a critical role in governing T follicular helper cell localization within lymph node germinal centers.
Understanding PD-1's function in Tfh cell positioning provides insights into adaptive immunity and B cell development.
Targeting PD-1 pathways could potentially modulate immune responses mediated by Tfh cells.