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Updated: Feb 4, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
Prostate Stem Cells and Cancer Stem Cells
Jia J Li1,2,3,4,5, Michael M Shen1,2,3,4,5
1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Abstract:
Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as in human tissue. We also discuss studies that have investigated the cell type of origin for prostate cancer. In addition, we provide a critical assessment of methodologies used in stem cell analyses and outline directions for future research.
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