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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Related Experiment Video

Updated: Feb 4, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

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Prostate Stem Cells and Cancer Stem Cells.

Jia J Li1,2,3,4,5, Michael M Shen1,2,3,4,5

  • 1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032.

Cold Spring Harbor Perspectives in Medicine
|October 7, 2018
PubMed
Summary
This summary is machine-generated.

Normal and cancer stem cells are crucial for organ development and tumor growth. This review examines prostate stem cells, cancer stem cells (CSCs), and their origins, assessing research methods and future directions.

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Area of Science:

  • Cell Biology
  • Oncology
  • Developmental Biology

Background:

  • Stem/progenitor cells are vital for organogenesis and tissue homeostasis.
  • Cancer stem cells (CSCs) are implicated in driving tumor malignancy.
  • Understanding prostate stem cells and CSCs is key to advancing prostate cancer research.

Purpose of the Study:

  • To review recent advancements in identifying and analyzing normal prostate stem/progenitor cells.
  • To discuss the identification and analysis of putative CSCs in prostate cancer.
  • To explore the cell type of origin for prostate cancer and critically assess methodologies.

Main Methods:

  • Review of recent scientific literature on prostate stem cells and CSCs.
  • Analysis of studies using genetically engineered mouse models.
  • Examination of research conducted on human prostate tissue.

Main Results:

  • Progress has been made in identifying and characterizing normal prostate stem/progenitor cells.
  • Evidence suggests the existence and role of CSCs in prostate cancer.
  • Studies are elucidating the cellular origins of prostate cancer.

Conclusions:

  • Further research is needed to fully understand the roles of stem cells in prostate cancer.
  • Methodological advancements are crucial for accurate stem cell analysis.
  • Future research should focus on refining techniques and exploring therapeutic strategies targeting CSCs.