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Antecedents of Obesity Among Children Born Extremely Preterm

Charles T Wood1, Olivia Linthavong2, Eliana M Perrin3

  • 1Division of Primary Care Pediatrics, Department of Pediatrics, Duke Center for Childhood Obesity Research, School of Medicine, Duke University, Durham, North Carolina; charles.wood@duke.edu.

Pediatrics
|October 7, 2018
PubMed

Insights

Maternal prepregnancy BMI and rapid infant weight gain increase childhood obesity risk. Risk factors for obesity in preterm infants at age 10 are similar to those in full-term infants.

Area of Science:

  • Pediatrics
  • Public Health
  • Neonatology

Background:

  • Childhood obesity is a significant public health concern.
  • Maternal prepregnancy BMI and rapid infant weight gain are known risk factors.
  • The association between early life growth and later obesity in preterm infants is unclear.

Purpose of the Study:

  • To investigate the relationship between early life factors and the risk of overweight and obesity at 10 years of age in children born extremely preterm.
  • To compare these risk profiles with those of children born at term.

Main Methods:

  • Prospective observational study using data from the Extremely Low Gestational Age Newborn Study.
  • Follow-up at 10 years of age for BMI assessment.
  • Multivariable regression analysis to identify risk factors for overweight and obesity.

Main Results:

  • High maternal prepregnancy BMI (≥25) and top quartile infant weight gain in the first year were associated with increased risk of overweight and obesity at 10 years.
  • Single marital status and exposure to tobacco smoke were also identified as risk factors.

Conclusions:

  • Risk profiles for overweight and obesity at 10 years of age in extremely preterm infants are similar to those in term-born infants.
  • Early life factors like maternal BMI and infant growth play a crucial role in later obesity risk.
Abstract

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