Cerebral small vessel disease: neuroimaging markers and clinical implication

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Xiaodong Chen1, Jihui Wang2, Yilong Shan1

  • 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.

Journal of Neurology
|October 7, 2018
PubMed

Insights

Cerebral small vessel disease (CSVD) involves various causes affecting small brain vessels. Neuroimaging markers help identify causes and predict stroke risk, cognitive decline, and quality of life.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Biology

Background:

  • Cerebral small vessel disease (CSVD) encompasses cerebrovascular conditions affecting small brain vessels.
  • Despite diverse etiologies, CSVD presents with shared neuroimaging markers.

Purpose of the Study:

  • To review the radiological characteristics of CSVD markers.
  • To discuss the clinical implications of these markers and neuroimaging interpretation for CSVD symptomatology.

Main Methods:

  • Review of literature on CSVD neuroimaging markers.
  • Analysis of radiological features and their etiological significance.
  • Correlation of CSVD burden with clinical outcomes.

Main Results:

  • Common CSVD neuroimaging markers include infarcts, lacunes, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds.
  • Radiological features aid in etiological analysis.
  • Total CSVD burden predicts stroke, cognitive impairment, psychiatric disorders, and quality of life.

Conclusions:

  • Neuroimaging markers are crucial for diagnosing and understanding CSVD.
  • Interpreting these markers provides insight into clinical manifestations and prognosis.

Keywords:
ArteriolosclerosisCerebral small vessel diseaseCognitionNeuroimaging markers

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