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CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets

Rosilene Motta Elias1,2, Maria Aparecida Dalboni1, Ana Carolina E Coelho3

  • 1Universidade Nove de Julho, UNINOVE, Rua Iperoig, 690 ap 121, São Paulo, SP, 05016-000, Brazil.

Current Osteoporosis Reports
|October 7, 2018
PubMed

Insights

Chronic kidney disease-mineral and bone disorder (CKD-MBD) pathophysiology is better understood, but treatments remain limited. New research highlights osteocyte dysfunction as a key factor, suggesting novel therapeutic targets for CKD-MBD.

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Biology

Background:

  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) remains a significant clinical challenge with high mortality.
  • Despite advances in understanding CKD-MBD pathophysiology, therapeutic options have not significantly improved patient outcomes or quality of life.

Purpose of the Study:

  • To review traditional and updated pathophysiology of CKD-MBD.
  • To discuss current therapeutic limitations and explore novel treatment targets for CKD-MBD.

Main Methods:

  • Literature review of recent advancements in CKD-MBD research.
  • Analysis of the role of osteocytes in CKD-MBD.
  • Discussion of emerging therapeutic strategies.

Main Results:

  • The osteocyte is now recognized as a central player in CKD-MBD, shifting from the traditional view of bone as a target organ.
  • Osteocytes, through factors like FGF-23 and sclerostin, act as endocrine regulators, suggesting dysregulation may be an early CKD event.
  • Current treatments for CKD-MBD face limitations, necessitating exploration of alternative approaches.

Conclusions:

  • A paradigm shift in understanding CKD-MBD positions osteocytes as key regulators, offering new avenues for therapeutic intervention.
  • Targeting osteocyte function presents a promising strategy to improve management and outcomes for CKD-MBD patients.
  • Further research into osteocyte-centric therapies is crucial for addressing the unmet needs in CKD-MBD treatment.
Abstract

Keywords:
CKD-MBDFGF-23OsteocyteSclerostinSecondary hyperparathyroidism

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