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Related Concept Videos

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of Infection01:26

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

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Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
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Sexually Transmitted Infections01:26

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi
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Fulminant Staphylococcal Infections.

Yves Gillet1, Thomas Henry2, Francois Vandenesch2

  • 1Department of Pediatric Emergency, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, F-69677, Bron, France.

Microbiology Spectrum
|October 7, 2018
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Summary
This summary is machine-generated.

Fulminant staphylococcal infections are severe, rapid-onset conditions like necrotizing pneumonia and fasciitis, often driven by toxins. This review covers their clinical, pathophysiological, and therapeutic aspects.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Toxicology

Background:

  • Fulminant staphylococcal infections present as explosive, severe, and life-threatening conditions.
  • These infections include necrotizing pneumonia, necrotizing fasciitis, toxic shock syndrome, and infective endocarditis.

Purpose of the Study:

  • To review the clinical, pathophysiological, and therapeutic aspects of fulminant staphylococcal infections.
  • To differentiate the role of toxin production in various presentations of severe staphylococcal disease.

Main Methods:

  • Literature review of clinical case studies and scientific articles.
  • Analysis of pathophysiological mechanisms and toxin involvement.
  • Synthesis of current therapeutic strategies.

Main Results:

  • Toxin production is a major factor in necrotizing pneumonia, necrotizing fasciitis, and toxic shock syndrome.
  • Fulminant infective endocarditis has not been demonstrably linked to specific toxin profiles.
  • Clinical presentations, disease progression, and treatment outcomes vary across these severe infections.

Conclusions:

  • Understanding the diverse mechanisms, particularly toxin involvement, is crucial for managing fulminant staphylococcal infections.
  • Tailored therapeutic approaches are necessary for different clinical manifestations.
  • Further research may elucidate specific toxin associations in infective endocarditis.