Related Experiment Video

Updated: Feb 4, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K

Postmarket Experience With HeartMate 3 Left Ventricular Assist Device: 30-Day Outcomes From the ELEVATE Registry

Jens Garbade1, Finn Gustafsson2, Steven Shaw3

  • 1University Department for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.

The Annals of Thoracic Surgery
|October 7, 2018
PubMed

Insights

Outcomes for HeartMate 3 left ventricular assist device patients in the ELEVATE registry were comparable to the CE Mark trial, even with sicker patients. Improved surgical techniques led to low adverse events and no early pump thrombosis.

Area of Science:

  • Cardiovascular Surgery
  • Medical Devices
  • Heart Failure Management

Background:

  • The HeartMate 3 left ventricular assist device (LVAD) offers enhanced hemocompatibility for advanced heart failure.
  • Surgical outcomes require comparison between initial clinical trials and post-market real-world data.

Purpose of the Study:

  • To compare surgical outcomes of HeartMate 3 LVAD implantation between the CE Mark (CEM) clinical trial and the post-market ELEVATE registry.
  • To evaluate the safety and efficacy of the HeartMate 3 in a broader patient population.

Main Methods:

  • Prospective, observational, multinational ELEVATE registry data were compared with data from the CEM trial.
  • Patient characteristics, 30-day survival, intensive care unit (ICU) stay, and adverse event rates were analyzed.
  • Statistical adjustments were made for baseline differences between groups.

Main Results:

  • The ELEVATE registry (N=463) included sicker patients (INTERMACS 1-2: 32% vs 10%) than the CEM trial (N=50).
  • 30-day survival was comparable (95% vs 98%; p=0.46) after adjustment.
  • Adverse event rates were similar, with lower arrhythmias in ELEVATE (13% vs 28%; p=0.009) and no early pump thrombosis.

Conclusions:

  • Comparable 30-day outcomes were achieved in the ELEVATE registry despite a sicker patient cohort.
  • Evolving implant techniques, including less invasive and off-pump approaches, contribute to favorable outcomes.
  • The HeartMate 3 demonstrates continued safety and efficacy in real-world post-market use.
Abstract

More Related Videos

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.1K

Related Concept Videos

Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
290
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.2K
What is an Experiment?01:12

What is an Experiment?

An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.3K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.9K