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Updated: Feb 4, 2026
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
The future R&D landscape in non-alcoholic steatohepatitis (NASH)
Darcey Black1, Sarah Brockbank2, Simon Cruwys1
1Innovative Medicines Unit, Grünenthal Innovation, Zieglerstrasse 6, 52078 Aachen, Germany; TherapeutAix, Juttastrasse 18, 52066 Aachen, Germany.
Abstract:
Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue for the 21st century and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. Consequently, NASH has become the focus of significant public and private research and development. In this review, we highlight the research and development (R&D) challenges and opportunities in this emerging therapeutic area. In particular, we consider the impact of the development of new biomarker strategies on clinical trial execution and design, and the positioning of single and combination therapies in future approaches to the treatment of NASH.
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