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Brain functional and effective connectivity underlying the information processing speed assessed by the Symbol Digit
P H R Silva1, C T Spedo2, C R Baldassarini2
1Dept. of Physics, FFCLRP, University of São Paulo, Ribeirão Preto, SP, Brazil.
Neuroimage
|October 8, 2018
Summary
Information Processing Speed (IPS) involves frontoparietal and temporoparietal brain networks. Understanding these networks aids in developing rehabilitation for attention deficits and cognitive impairments.
Area of Science:
- Neuroscience
- Cognitive Science
- Neuroimaging
Background:
- Delayed Information Processing Speed (IPS) is a key cognitive deficit in various neurological and psychiatric conditions, including traumatic brain injury, Parkinson's disease, depression, dementia, and multiple sclerosis.
- Understanding the neural underpinnings of IPS is crucial for developing targeted interventions and rehabilitation strategies.
Purpose of the Study:
- To elucidate the brain network responsible for Information Processing Speed (IPS) in healthy individuals.
- To model the functional and effective connectivity underlying IPS using neuroimaging techniques.
Main Methods:
- Utilized functional magnetic resonance imaging (fMRI) on 16 healthy volunteers performing an adapted Symbol Digit Modalities Test.
- Employed dynamic causal modeling (DCM) to analyze brain functional and effective connectivity during the IPS task.
Main Results:
- Identified two interacting brain systems crucial for IPS: frontoparietal/fronto-occipital networks (goal-directed selection) and temporoparietal/inferior frontal cortices (stimulus-driven attention).
- Observed a significant correlation between the default-mode network and task-positive networks involved in visual processing, highlighting its role in functional integration for IPS.
Conclusions:
- Proposed a novel brain network model for Information Processing Speed (IPS) in healthy subjects.
- The methodology offers a framework for future research on IPS in clinical populations and longitudinal studies.
Keywords:
Dynamic causal modelingEffective connectivityFunctional connectivityInformation processing speedMore Related Videos
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