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Updated: Feb 4, 2026
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Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer
Published on: October 13, 2023
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Measurement of Multiple Solid Portions in Part-Solid Nodules for T Categorization: Evaluation of Prognostic
Hyungjin Kim1, Jin Mo Goo2, Young Joo Suh3
1Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Summary
The number of solid portions in part-solid nodules (PSNs) does not impact disease-free survival in lung adenocarcinoma. Current clinical T categorization using the single largest solid portion measurement is appropriate for risk stratification.
Area of Science:
- Pulmonary medicine
- Thoracic oncology
- Radiology
Background:
- Part-solid nodules (PSNs) are common findings in lung cancer screening.
- Accurate prognostic assessment of PSNs is crucial for guiding treatment decisions.
- The role of solid portion multiplicity in PSNs requires further investigation.
Purpose of the Study:
- To evaluate the prognostic significance of solid portion multiplicity in part-solid nodules (PSNs) of lung adenocarcinoma.
- To compare the prognostic performance of different solid portion measurements for risk stratification.
- To assess the appropriateness of current clinical T categorization for PSNs.
Main Methods:
- Retrospective review of 345 surgically resected stage IA lung adenocarcinomas presenting as PSNs.
- Measurement of solid portion multiplicity and diameters within PSNs.
- Cox regression analysis for disease-free survival (DFS) and concordance index (C-index) comparison of various solid portion metrics.
Main Results:
- Solid portion multiplicity did not significantly affect DFS.
- Clinical T category, based on the single largest solid portion, was the sole independent risk factor for recurrence (p < 0.05).
- The C-index for the single solid portion measurement was 0.817, with no significant difference compared to other measures; substantial interreader variability was noted.
Conclusions:
- The current clinical T categorization of PSNs, relying on single solid portion measurement, is appropriate for prognostic assessment.
- Solid portion multiplicity is not a significant prognostic factor for stage IA lung adenocarcinoma.
- Further refinement of measurement techniques may be needed due to interreader variability.
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