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DNA damaging agent-based antibody-drug conjugates for cancer therapy

Ying Fu1, Mitchell Ho1

  • 1Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA.

Antibody Therapeutics
|October 9, 2018
PubMed

Insights

Antibody-drug conjugates (ADCs) are advancing cancer therapy. This review explores DNA-damaging agents as novel payloads for ADCs, moving beyond traditional microtubule inhibitors for improved treatment strategies.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Four antibody-drug conjugates (ADCs) are approved for cancer treatment, with over 60 in clinical development.
  • Microtubule inhibitors are used as payloads in over 60% of ADCs in clinical trials.
  • Understanding alternative payloads, particularly DNA-damaging agents, is crucial for ADC advancement.

Purpose of the Study:

  • To highlight the emerging trend of utilizing DNA-damaging agents as payloads in ADCs.
  • To summarize recent clinical findings on DNA-damaging payloads for ADCs.
  • To define the therapeutic utility of DNA-damaging payloads in cancer treatment.

Main Methods:

  • Review of current clinical studies on ADCs.
  • Analysis of emerging trends in ADC payload selection.
  • Discussion of future directions in ADC development.

Main Results:

  • DNA-damaging agents represent an emerging class of payloads for ADCs.
  • Clinical studies are providing insights into the efficacy of DNA-damaging payloads.
  • This approach offers potential for improved cancer therapeutics.

Conclusions:

  • DNA-damaging agents are a promising alternative to microtubule inhibitors as ADC payloads.
  • Further research is needed to fully define their utility in cancer therapy.
  • Future directions include targeting drug resistance and combination treatments with immunotherapy.
Keywords:
DNA-damaging agentantibody-drug conjugatecancer therapydrug resistance

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