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Updated: Feb 4, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Published on: June 3, 2014
[Coagulation Properties for Whole Blood Stored at 4℃].
Shu-Jun Wang1, Xiao-Bao Shao1, Na Li1
1Department of Blood Transfusion, Nanjing General Hospital of Chinese PLA, Nanjing 210002, Jiangsu Province, China.
Refrigerated whole blood stored for up to 10 days maintains normal coagulation function. This finding is crucial for managing hemorrhage in trauma and surgical patients, ensuring effective blood transfusion strategies.
Area of Science:
- Transfusion Medicine
- Hematology
- Biochemistry
Background:
- Refrigerated whole blood is a critical resource in emergency medicine.
- Understanding its coagulation properties during storage is essential for patient safety and treatment efficacy.
Purpose of the Study:
- To assess the coagulation function of whole blood stored at 4°C for up to 21 days.
- To determine the optimal storage duration for maintaining effective hemostatic properties.
Main Methods:
- Ten units of whole blood were stored at 4±2°C for 21 days.
- Coagulation parameters including complete blood count, electrolytes, activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fg), coagulation factors, and thromboelastography (TEG) were analyzed at various time points.
Main Results:
- Hemoglobin, white blood cell, platelet, and sodium levels decreased, while potassium increased with storage duration.
- APTT and PT prolonged over time, with PT exceeding 17 minutes by day 21.
- Coagulation factors V and VIII decreased significantly by days 6 and 4, respectively. TEG showed abnormalities in K and Angle by day 21 and in Maximum Amplitude (MA) by day 14.
Conclusions:
- Whole blood stored for 10 days retains normal coagulation function.
- This extended viability is significant for treating hemorrhage in war injuries and cardiothoracic surgery.
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