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CXCL4 contributes to host defense against acute Pseudomonas aeruginosa lung infection

Lei Yue1, Zheng Pang2, Hua Li1

  • 1The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China.

Plos One
|October 9, 2018
PubMed

Insights

Platelet chemokine CXCL4 is vital for clearing Pseudomonas aeruginosa lung infections by recruiting neutrophils and enhancing bacterial killing. Its deficiency increases mortality and impairs bacterial clearance in mice.

Area of Science:

  • Immunology
  • Pulmonology
  • Microbiology

Background:

  • Platelets are involved in pulmonary inflammation from bacterial stimuli.
  • Mechanisms of platelet-mediated host response in respiratory bacterial infections are not fully understood.

Purpose of the Study:

  • To investigate the role of platelet-derived chemokine (C-X-C motif) ligand 4 (CXCL4) in acute bacterial pneumonia caused by Pseudomonas aeruginosa.

Main Methods:

  • Utilized a mouse model of acute bacterial pneumonia induced by P. aeruginosa.
  • Examined platelet activation, mortality, bacterial clearance, and neutrophil recruitment in wild-type and CXCL4-deficient mice.
  • Assessed platelet-neutrophil interactions and the impact of CXCL4 on neutrophil bacterial killing.

Main Results:

  • Platelets are activated during P. aeruginosa infection; platelet depletion increases mortality and impairs bacterial clearance.
  • CXCL4 deficiency impairs bacterial clearance, lung epithelial permeability, and neutrophil recruitment to bronchoalveolar lavage fluid (BALF).
  • CXCL4 deficiency reduces platelet-neutrophil interactions and impairs P. aeruginosa-killing by neutrophils.

Conclusions:

  • Platelet-derived CXCL4 is critical for bacterial clearance during P. aeruginosa pneumonia.
  • CXCL4 promotes neutrophil recruitment to the lungs and enhances intracellular bacterial killing.
  • CXCL4 plays a vital role in the host defense against respiratory bacterial infections.

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