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Synthesis and antiproliferative activity of 17-[1',2',3']-selenadiazolylpregnenolone compounds
Jianguo Cui1, Liping Pang2, Meizhen Wei2
1College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, PR China; College of Petroleum and Chemical Engineering, Qizhou University, Qizhou, PR China.
Abstract:
Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The results show that some compounds display selective antiproliferative activity against PC-3 and SKOV3 cells lines and are almost inactive to normal kidney epithelial cells (HEK293T). The IC50 value are much better than that of abiraterone (positive control).