Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

98.1K
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
98.1K
The Evidence for Evolution02:55

The Evidence for Evolution

48.2K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.2K
Convergent Evolution01:54

Convergent Evolution

32.9K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
32.9K
Self-Help Support Groups01:28

Self-Help Support Groups

352
Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...
352
Eukaryotic Evolution01:24

Eukaryotic Evolution

41.4K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
41.4K
Synteny and Evolution02:31

Synteny and Evolution

3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary medical management of left ventricular assist device patients: integrating sex-specific perspectives.

Current opinion in cardiology·2026
Same author

Humanistic Machines: Designing Devices for People With Heart Failure With a Focus on Multidisciplinary Human Factors Research.

JACC. Heart failure·2026
Same author

Donor-Derived Cell-Free DNA Stratifies Risk of Mortality and Graft Dysfunction in Severe Acute Cardiac Allograft Rejection.

Circulation. Heart failure·2026
Same author

Donor-Derived Cell-Free DNA as a Prognostic Biomarker After Heart Transplantation: The DEFINE-HT Study.

JACC. Heart failure·2026
Same author

Ambulatory Stage C2D Heart Failure Definitions and Current Therapeutic Approaches: JACC: Heart Failure Position Statement.

JACC. Heart failure·2026
Same author

The Role of Mechanical Circulatory Support Devices in Heart Failure Cardiogenic Shock.

Interventional cardiology clinics·2026

Related Experiment Video

Updated: Feb 4, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

652

The Evolution of Mechanical Circulatory Support.

Ju H Kim1, Jennifer A Cowger2, Palak Shah3

  • 1Department of Heart Failure and Transplantation, Houston Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA.

Cardiology Clinics
|October 10, 2018
PubMed
Summary

Mechanical circulatory support (MCS) devices have advanced, improving survival and quality of life for advanced heart failure patients. Ongoing research focuses on reducing adverse events through enhanced biocompatibility.

Keywords:
Cardiac transplantationHeart failureMechanical circulatory supportTotal artificial heartVentricular assist device

More Related Videos

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

2.0K
Investigation of Early Plasma Evolution Induced by Ultrashort Laser Pulses
11:20

Investigation of Early Plasma Evolution Induced by Ultrashort Laser Pulses

Published on: July 2, 2012

15.5K

Related Experiment Videos

Last Updated: Feb 4, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

652
Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

2.0K
Investigation of Early Plasma Evolution Induced by Ultrashort Laser Pulses
11:20

Investigation of Early Plasma Evolution Induced by Ultrashort Laser Pulses

Published on: July 2, 2012

15.5K

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Medical Devices

Background:

  • Mechanical circulatory support (MCS) has evolved significantly from early pulsatile-flow devices.
  • Current continuous-flow devices enable patient mobility and improved quality of life.

Purpose of the Study:

  • To review the evolution and current state of mechanical circulatory support (MCS) technology.
  • To highlight the benefits of left ventricular assist devices (LVADs) in advanced heart failure.
  • To identify challenges and ongoing research in MCS therapy.

Main Methods:

  • Review of existing literature on mechanical circulatory support (MCS) devices.
  • Analysis of technological advancements in pulsatile-flow versus continuous-flow systems.
  • Examination of clinical outcomes and adverse events associated with MCS therapy.

Main Results:

  • Newer-generation continuous-flow MCS devices allow for hospital discharge and normal life activities.
  • Left ventricular assist devices (LVADs) demonstrate improved long-term survival and quality of life for advanced heart failure patients.
  • Adverse events remain a significant challenge in MCS therapy.

Conclusions:

  • Mechanical circulatory support (MCS) has transformed the management of advanced heart failure.
  • Continuous-flow LVADs offer substantial benefits for both transplant-eligible and ineligible patients.
  • Improving biocompatibility is crucial for mitigating adverse events and advancing MCS technology.