The Thermodynamics of Development in Bioartificial Tissue Design

The fabrication of bioartificial tissues with authentic structures that could assure their clinical efficacy remains a challenging problem. A new paradigm has emerged that designs bioartificial tissues as intermediate in development tissue forms, which can inherently progress autonomously on developmental pathways, self-organizing their cells into tissue structures as in their in vivo development. Biological processes involved in energy exchange between co-developing tissues are responsible for cell organization into the thermodynamically robust cellular patterns of tissue structures. Bioartificial tissue design rules that aim towards in vitro recapitulation of these processes can ensure the thermodynamic operation of developing tissues, leading to formation of the cellular patterns of tissue structures.