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Updated: Feb 4, 2026

Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management
Published on: September 12, 2017
[Dermatofibrosarcoma: Management]
Nicolas Penel1, Sophie El Bedoui2, Yves-Marie Robin3
1Centre Oscar Lambret, département de cancérologie générale, 3, rue F. Combemale, 59020 Lille, France; CHRU de Lille, hôpital Claude-Huriez, service universitaire d'oncologie médicale, rue Michel-Polonowski, 59037 Lille, France.
Abstract:
Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). The risk of metastatic relapse is low (and related to fibrosarcoma component); the risk of local relapse depends on the quality of surgery. Management of localized DFSP is based on large resection with meticulous analysis of margins (with or without Mohs microsurgery). Advanced stages not amenable to surgery or metastatic DFSP (with presence of COL1A1;PDGFB) are best treated with imatinib. Locally advanced DFSP potentially amenable to curative intent surgery could be treated with imatinib as neo-adjuvant treatment. The management of these tumours requires multidisciplinary expertise.
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