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Updated: Feb 4, 2026

Harvesting Sperm and Artificial Insemination of Mice
Published on: April 28, 2007
Does intra-uterine insemination have a place in modern ART practice?
Valarmathy Kandavel1, Ying Cheong1
1Complete Fertility Ltd, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Complete Fertility Ltd, Southampton, United Kingdom.
Abstract:
Intra-uterine insemination (IUI) is a cheaper, less intensive treatment modality for achieving a pregnancy in couples with specific indications. The use of IUI seems to have declined after NICE guideline 2013 (CG 156) recommended IVF over IUI in couples with unexplained and mild male factor infertility. This review examines the current evidence and the applicability of IUI as a first-line option of treatment in couples with unexplained and mild male factor subfertility. The outcome of the review supports this argument. It is likely that IUI will re-emerge as an effective treatment option and thereby increase the choice to patients. However, there is a need for ongoing research and investment into funding of good quality trials to improve and strengthen the evidence base.
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