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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
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Pericardial sarcoma.
Mahmoud Abdelnaby1, Abdallah Almaghraby2, Yehia Saleh2,3
1Department of Cardiology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
BMJ Case Reports
|October 10, 2018
Summary
Pericardial sarcomas, rare aggressive heart tumors, present with vague symptoms. This case highlights successful diagnosis and treatment of a high-grade undifferentiated sarcoma of the pericardium.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Pericardial sarcomas are rare, aggressive neoplasms with non-specific symptoms.
- Multimodality imaging is crucial for diagnosing cardiac masses.
- These tumors are often fatal despite treatment.
Observation:
- A 27-year-old female presented with dyspnea and signs of cardiac tamponade.
- Transthoracic echocardiography revealed a pericardial effusion and mass.
- CT imaging showed the mass compressing the right atrium.
Findings:
- Pericardiocentesis yielded hemorrhagic fluid.
- Excision biopsy confirmed a high-grade undifferentiated sarcoma of the pericardium.
- Histopathology revealed a well-circumscribed mass with hemorrhage and necrosis.
Implications:
- Early and accurate diagnosis through multimodality imaging is vital.
- Aggressive surgical and adjuvant therapy (chemotherapy, radiotherapy) can lead to favorable outcomes.
- This case suggests potential for successful management of pericardial sarcomas.
