Isoniazid-induced pure red cell aplasia
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Updated: Feb 4, 2026

OnePot PURE Cell-Free System
Published on: June 23, 2021
Subraya Krishna Holla1, Basavaprabhu Achappa1, Pavan Manibettu Raguram1
1Department of Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, India.
Abstract:
The pure red cell aplasia (PRCA) is an uncommon side effect of isoniazid. We describe a 28-year-old man who developed a severe anaemia caused by PRCA. The patient received antituberculous therapy including isoniazid for his pulmonary tuberculosis. On discontinuation of isoniazid, the anaemia recovered promptly. PRCA should be considered in case of unexplained anaemia during isoniazid treatment.
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