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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Third generation antibody discovery methods: in silico rational design

Pietro Sormanni1, Francesco A Aprile, Michele Vendruscolo

  • 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ps589@cam.ac.uk mv245@cam.ac.uk.

Chemical Society Reviews
|October 10, 2018
PubMed

Owing to their outstanding performances in molecular recognition, antibodies are extensively used in research and applications in molecular biology, biotechnology and medicine. Recent advances in experimental and computational methods are making it possible to complement well-established in vivo (first generation) and in vitro (second generation) methods of antibody discovery with novel in silico (third generation) approaches. Here we describe the principles of computational antibody design and review the state of the art in this field. We then present Modular, a method that implements the rational design of antibodies in a modular manner, and describe the opportunities offered by this approach.

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