Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.6K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.6K
Complementation Tests00:49

Complementation Tests

6.2K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.2K
Glomerular Filtration01:15

Glomerular Filtration

5.4K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
5.4K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.4K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.4K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

233
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
233
Glomerular Filtration: Net Filtration Pressure01:26

Glomerular Filtration: Net Filtration Pressure

8.2K
Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxalate Nephropathy and the Mechanism of Oxalate-Induced Kidney Injury.

Kidney diseases (Basel, Switzerland)·2023
Same author

The Prevalence and Characteristics of Circulating IgA Anti-Glomerular Basement Membrane Autoantibodies in Anti-Glomerular Basement Membrane Disease.

Kidney international reports·2023
Same author

Association of serum potassium level with dietary potassium intake in Chinese older adults: a multicentre, cross-sectional survey.

BMJ open·2023
Same author

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis.

Kidney diseases (Basel, Switzerland)·2023
Same author

Association between alkaline phosphatase/albumin ratio and the prognosis in patients with chronic kidney disease stages 1-4: results from a C-STRIDE prospective cohort study.

Frontiers in medicine·2023
Same author

Characteristics of Complement Protein Deposition in Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition.

Clinical journal of the American Society of Nephrology : CJASN·2023
Same journal

Paroxysmal Cold Haemoglobinuria: A Chilling Case of Acute Renal Failure.

Nephrology (Carlton, Vic.)·2026
Same journal

Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis.

Nephrology (Carlton, Vic.)·2026
Same journal

Injury to E- and VE-Cadherin in Paediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: Potential Markers of the Disease Status.

Nephrology (Carlton, Vic.)·2026
Same journal

Finerenone in Treating a 12-Year-Old Boy Suffering Gitelman Syndrome Without Causing Gynecomastia.

Nephrology (Carlton, Vic.)·2026
Same journal

NCOA4-Mediated Ferroptosis Drives Tubulointerstitial Fibrosis in Hyperuricemia-Associated Chronic Kidney Disease.

Nephrology (Carlton, Vic.)·2026
Same journal

Comment on 'Chronic Kidney Disease-Associated Pruritus in Patients on Home Haemodialysis'.

Nephrology (Carlton, Vic.)·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.6K

Complement in glomerular diseases.

Ying Tan1,2,3,4, Ming-Hui Zhao1,2,3,4,5

  • 1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Nephrology (Carlton, Vic.)
|October 10, 2018
PubMed
Summary
This summary is machine-generated.

Complement activation is crucial in various glomerulonephritis, including lupus nephritis and vasculitis. Targeting the complement system offers potential new therapies for these kidney diseases.

Keywords:
ComplementGlomerular diseasePathogenesis

More Related Videos

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

23.3K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.0K

Related Experiment Videos

Last Updated: Feb 4, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.6K
Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

23.3K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.0K

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Background:

  • Complement activation is implicated in the pathogenesis of numerous glomerulonephritis conditions.
  • It plays a direct role in thrombotic microangiopathy and C3 glomerulopathy.
  • It also contributes significantly to lupus nephritis and anti-neutrophil cytoplasmic antibody-associated vasculitis.

Purpose of the Study:

  • To elucidate the role of complement activation in the pathogenesis of various glomerulonephritis.
  • To explore the potential of complement system as a therapeutic target.

Main Methods:

  • Review of recent studies on complement activation in glomerulonephritis.
  • Analysis of the pathogenic mechanisms involved.

Main Results:

  • Complement activation is a key factor in thrombotic microangiopathy, C3 glomerulopathy, lupus nephritis, and anti-neutrophil cytoplasmic antibody-associated vasculitis.
  • Emerging evidence suggests a role in immunoglobulin A nephropathy and focal segmental glomerulosclerosis.
  • Monoclonal immunoglobulins can interfere with complement, leading to glomerulonephritis.

Conclusions:

  • Understanding complement's role in glomerulonephritis is vital for identifying new therapeutic strategies.
  • Targeting the complement system presents a promising avenue for treating these kidney diseases.