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One-Pot Approach for the Synthesis of Bis-indole-1,4-disubstituted-1,2,3-triazoles
Natthiya Saehlim1, Teerapich Kasemsuk2, Uthaiwan Sirion1
1Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science , Burapha University , Sangesook , Chonburi 20131 , Thailand.
Abstract:
A new strategy for the synthesis of bis-indoletriazoles was developed using a sequential one-pot four-step procedure via I2 and H2SO4-SiO2 catalyzed Friedel-Crafts reactions of indole with aldehyde followed by N-alkylation with propargyl bromide, azidation, and copper(I)-catalyzed azide alkyne cycloaddition (CuAAC). The reaction proceeded smoothly at room temperature in a short time, and a series of bis-indoletriazoles were obtained in good to excellent yields proving the generality of this one-pot methodology.
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