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Updated: Feb 4, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Re-entrant supramolecular interactions in inverse-melting α-cyclodextrin·4-methylpyridine·water mixtures: an NMR
Reut Shapira1, Yael S Balazs, Shifi Kababya
1Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Technion City, 3200008, Haifa, Israel. yoav@ch.technion.ac.il.
Abstract:
Inverse melting α-cyclodextrin·4-methylpyridine·H2O ternary mixtures were studied via solution, high-resolution magic-angle-spinning and 2D-NOESY NMR spectroscopy with the aim of unveiling the supramolecular driving force for the unusual inverse-melting phase transition. The role of solvent-solvent interactions as well as solvent-solute interactions in the emergence of the inverse-melting phenomenon is revealed. A surprising re-entrant solvent-solvent interaction is found in the system and in the 4-methylpyridine·water solvent system, supporting the non-coincidental relationship between inverse melting and re-entrant phase transitions, at least in the present system.
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