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Updated: Feb 4, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
12.0K
Positive factors, pain, and function in adults with multiple sclerosis.
Anne Arewasikporn1, Dawn M Ehde1, Kevin N Alschuler1
1Department of Rehabilitation Medicine.
Rehabilitation Psychology
|October 10, 2018
Summary
Positive affect and resilience in multiple sclerosis (MS) do not directly buffer pain
Area of Science:
- Psychology and Neuroscience
- Clinical Research
- Chronic Pain Management
Background:
- Chronic pain significantly impacts individuals with multiple sclerosis (MS), affecting daily function and mood.
- While negative factors are well-studied, the role of positive factors like positive affect (PA) and resilience in MS pain adjustment is less understood.
- Understanding these positive factors is crucial for developing comprehensive management strategies for MS-related pain.
Purpose of the Study:
- To investigate whether positive affect (PA) and trait resilience moderate the relationship between pain intensity and functional outcomes (pain interference, depressive symptoms) in individuals with MS.
- To examine if trait resilience mediates the association between PA and functional outcomes in adults with MS.
- To clarify the mechanisms through which positive psychological factors influence adjustment to chronic pain in MS.
Main Methods:
- A cross-sectional survey was administered to 455 adults diagnosed with multiple sclerosis (MS).
- Path analysis was employed to examine moderation and mediation effects, controlling for relevant covariates.
- Key variables included pain intensity, positive affect (PA), trait resilience, pain interference, and depressive symptoms.
Main Results:
- Positive affect (PA) and trait resilience did not significantly moderate the association between pain intensity and pain interference or depressive symptoms.
- Trait resilience significantly mediated the relationship between PA and both pain interference and depressive symptoms.
- These findings suggest an indirect pathway where PA influences resilience, which in turn impacts functional outcomes.
Conclusions:
- Positive affect (PA) appears to indirectly benefit individuals with MS by enhancing resilience, rather than directly protecting against pain interference and depression.
- The results support theoretical models where positive experiences build personal resources, contributing to better coping mechanisms.
- Further research is warranted to explore interventions aimed at increasing PA and resilience to improve pain outcomes in the MS population.
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