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Mapping 241Am Spatial Distribution Within Anatomical Bone Structures Using Digital Autoradiography
George Tabatadze1, Brian W Miller2,3, Sergei Y Tolmachev1
1US Transuranium and Uranium Registries, College of Pharmacy, Washington State University, 1845 Terminal Drive, Suite 201, Richland, WA 99354.
Health Physics
|October 10, 2018
Summary
Digital autoradiography effectively visualizes Americium-241 (Am) microdistribution in bone. This method accurately quantifies radionuclide activity, proving superior to traditional techniques for heterogeneous samples.
Area of Science:
- Radiological Science
- Nuclear Medicine
- Biophysics
Background:
- Investigating radionuclide distribution in human bone is crucial for understanding internal contamination.
- Traditional methods for quantifying radionuclide activity in bone can be impractical for microscale analysis.
Observation:
- Digital autoradiography using the ionizing radiation quantum imaging detector was applied to bone samples from US Transuranium and Uranium Registries case 0846.
- Multiple bone specimens (humerus, clavicle) were sectioned and imaged to visualize Americium-241 (Am) distribution.
- Detector images were superimposed on anatomical images to map Am in cortical bone, trabecular bone, and spongiosa.
Findings:
- Americium-241 (Am) distribution was successfully visualized and quantified at a microscale within different bone regions.
- Activity concentration ratios (trabecular-to-cortical, spongiosa-to-cortical) were calculated for humerus and clavicle samples.
- Results from digital autoradiography showed strong agreement with radiochemical analysis and were compared to ICRP biokinetic model predictions.
Implications:
- Digital autoradiography is an effective method for studying microscale heterogeneous radionuclide distribution in bone.
- This technique offers a practical alternative to traditional counting methods for complex samples.
- Findings contribute to improved biokinetic modeling and risk assessment for internal radionuclide contamination.
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