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Mesenchymal stromal cell therapy in intestinal diseases
Rachele Ciccocioppo1, Marzia Fioravante, Luca Frulloni
1Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi & University of Verona, Verona, Italy.
Current Opinion in Organ Transplantation
|October 10, 2018
Summary
Mesenchymal stromal cells (MSCs) show promise for treating immune-mediated intestinal disorders like Crohn's disease. While safe for luminal symptoms, efficacy for fistulizing Crohn's led to an approved therapy, but broader clinical use faces regulatory hurdles.
Area of Science:
- Immunology
- Gastroenterology
- Regenerative Medicine
Background:
- Mesenchymal stromal cells (MSCs) possess immunomodulatory and regenerative properties.
- Their low immunogenicity makes them attractive for cell therapy.
- Significant preclinical data supports MSCs for immune-mediated conditions.
Purpose of the Study:
- To review the application and outcomes of MSC-based immunotherapies for intestinal disorders.
- To focus on available results from clinical studies.
Main Methods:
- Review of clinical trials and available data on MSC therapy for intestinal diseases.
- Analysis of MSC applications in Crohn's disease (luminal and fistulizing phenotypes).
Main Results:
- MSC therapy is feasible and safe for luminal Crohn's disease via intravenous infusion.
- Efficacy for luminal Crohn's requires further definitive conclusions.
- Local MSC injections show efficacy for fistulizing Crohn's, leading to regulatory approval (darvadstrocel).
Conclusions:
- MSC therapy is a promising approach for immune-mediated intestinal disorders.
- Regulatory and methodological challenges impede widespread clinical adoption.
- Interdisciplinary collaboration is essential for advancing MSCs to bedside application.
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