Encapsulation and Release of Essential Oils in Functional Silica Nanocontainers

We describe the fabrication of mesoporous silica nanocontainers (SiO₂NCs) that simultaneously encapsulate different antiseptic agents. Peppermint oil (PO), thyme oil (TO), cinnamon oil (CnO), and clove oil (CO), which are known to display antibacterial properties, are loaded in the core of the silica nanocontainers that are stabilized by antiseptic surfactants. The encapsulation efficiency, surface area, and pore size are controlled by the type of oil and surfactant. The release of essential oils is further controlled by grafting oxidized hyaluronic acid on silica nanocontainers functionalized with amino groups.