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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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PI3K pathway in prostate cancer: All resistant roads lead to PI3K

Soonbum Park1, Young Sik Kim1, Davis Yeon Kim1

  • 1Department of Physiology and Biomedical Sciences, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea.

Biochimica Et Biophysica Acta. Reviews on Cancer
|October 10, 2018
PubMed

Insights

The phosphoinositide 3-kinase (PI3K) pathway promotes cancer cell survival and resistance to treatment. Understanding PI3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The phosphoinositide 3-kinase (PI3K) pathway is crucial for cell survival, growth, and metabolism.
  • Aberrant PI3K pathway activation is common in prostate cancer, correlating with poor clinical outcomes.
  • Hyperactivation of the PI3K pathway enhances cancer cell adaptability and resilience.

Purpose of the Study:

  • To review challenges in targeting the PI3K pathway in prostate cancer.
  • To highlight the role of the PI3K pathway in treatment resistance.
  • To discuss strategies for overcoming therapeutic resistance.

Main Methods:

  • Literature review of PI3K pathway in prostate cancer.
  • Analysis of genetic and epigenetic alterations affecting the PI3K pathway.
  • Examination of molecular mechanisms of resistance to PI3K inhibitors.

Main Results:

  • Prostate cancer cells exploit the PI3K pathway to develop resistance to various anticancer treatments.
  • Specific molecular mechanisms contribute to resistance against PI3K pathway inhibitors.
  • Combination therapies show promise for overcoming resistance.

Conclusions:

  • Targeting the PI3K pathway in prostate cancer presents significant therapeutic challenges.
  • Understanding resistance mechanisms is vital for developing effective treatment strategies.
  • Translating biological insights into clinical therapies is essential for improving patient outcomes.
Keywords:
Cancer therapyPI3KProstate cancerResistance

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