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Updated: Feb 4, 2026
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3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
Published on: April 24, 2019
10.2K
Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing
Jinxin Yan1, Yu Wang1, Xuan Zhang2
1School of Life science and engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
International Journal of Biological Macromolecules
|October 10, 2018
Summary
This study developed a novel hydrogel from natural polysaccharides for drug delivery. Different patch shapes significantly impacted drug release rates, showing potential for controlled release applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Hydrogels are valuable in medicine due to water retention, biocompatibility, and biodegradability.
- Active polysaccharides from traditional Chinese medicine and carboxymethyl chitosan offer unique properties for hydrogel formation.
Purpose of the Study:
- To create and characterize a novel composite hydrogel from natural polysaccharides and carboxymethyl chitosan.
- To investigate the influence of 3D printed patch shape on drug release kinetics.
Main Methods:
- Composite hydrogel synthesis and characterization using SEM, FTIR, swelling, degradation, and cytotoxicity tests.
- Fabrication of hydrogel patches in circular, cube, and rectangular shapes via hot-melt extrusion 3D printing.
- In vitro drug release studies of Bovine Serum Albumin (BSA) under acidic and alkaline conditions.
Main Results:
- The composite hydrogel exhibited favorable characteristics suitable for medical applications.
- 3D printed hydrogel patches demonstrated varying drug release profiles based on shape.
- BSA cumulative release rates ranged from 49% to 89% across different shapes and pH conditions, indicating shape-dependent release.
Conclusions:
- The developed hydrogel exhibits significant potential for advanced drug delivery systems.
- Hydrogel patch geometry is a critical factor influencing drug release rates.
- This research highlights a promising biomaterial for tailored therapeutic applications.
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