Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Schizophrenia01:17

Schizophrenia

964
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
964
The Resting Membrane Potential01:21

The Resting Membrane Potential

142.6K
Overview
142.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

607
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
607
Genomics02:02

Genomics

40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K
Pilot and Numeric Relaying01:21

Pilot and Numeric Relaying

492
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
492
Resting Membrane Potential01:24

Resting Membrane Potential

21.8K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
21.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same author

Sensorimotor recovery and neuropathic pain reduction after remotely delivered cognitive multisensory rehabilitation or remotely delivered exercise in adults with spinal cord injury: a pilot clinical trial.

medRxiv : the preprint server for health sciences·2026
Same author

AI-associated delusions: terminology.

The lancet. Psychiatry·2026
Same author

Largely Typical Neural Activation During Monetary Reward Receipt in People With Psychosis-Spectrum Disorders and First-Degree Relatives.

Schizophrenia bulletin·2026
Same author

Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis.

JAMA psychiatry·2026
Same author

Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.

NeuroImage. Clinical·2026

Related Experiment Video

Updated: Feb 4, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

411.8K

A framework for linking resting-state chronnectome/genome features in schizophrenia: A pilot study.

Barnaly Rashid1, Jiayu Chen2, Ishtiaque Rashid3

  • 1Harvard Medical School, Boston, MA, USA; The Mind Research Network & LBERI, Albuquerque, NM, USA.

Neuroimage
|October 10, 2018
PubMed
Summary

Researchers found a link between dynamic functional network connectivity (dFNC) and genetic risk in schizophrenia. This suggests dFNC patterns could serve as imaging biomarkers for the disorder.

Keywords:
Dynamic functional connectivityMultimodal analysisParallel ICAResting-state fMRISchizophreniaSingle nucleotide polymorphism

More Related Videos

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.4K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.6K

Related Experiment Videos

Last Updated: Feb 4, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

411.8K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.4K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Psychiatric disorders like schizophrenia are complex, with genetic and brain imaging components.
  • Understanding the interplay between genetic factors and brain abnormalities is crucial.

Purpose of the Study:

  • To develop a novel multimodal framework integrating functional magnetic resonance imaging (fMRI) and single nucleotide polymorphism (SNP) data.
  • To investigate the association between dynamic functional network connectivity (dFNC) and genetic risk in schizophrenia.

Main Methods:

  • Utilized functional (dFNC) and genetic (SNP) data from 61 schizophrenia patients and 87 healthy controls.
  • Employed group independent component analysis (ICA) and k-means clustering to estimate dFNC states.
  • Applied a parallel ICA (pICA) framework to analyze imaging-genomic associations.

Main Results:

  • Identified a significant association between a SNP component and a dFNC component in schizophrenia.
  • Found a negative correlation between polygenic risk score (PRS) for schizophrenia and a specific dFNC component.
  • Observed that this dFNC component had lower occupancy in schizophrenia patients compared to controls.

Conclusions:

  • Preliminary evidence suggests a link between dFNC measures and genetic risk in schizophrenia.
  • dFNC patterns show potential as imaging biomarkers in imaging-genomic association studies for psychiatric disorders.