Related Experiment Video

Updated: Feb 4, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Management of non-metastatic castrate-resistant prostate cancer: A systematic review

Yohann Loriot1, Stéphane Supiot2, Jean-Baptiste Beauval3

  • 1Medical Oncology Department, Gustave Roussy, Université Paris-Saclay, Paris, France.

Cancer Treatment Reviews
|October 10, 2018
PubMed

Insights

New hormone therapies like apalutamide and enzalutamide offer improved treatment options for non-metastatic castration-resistant prostate cancer. This systematic review examines these new generation hormone therapies (NGHT) for managing this challenging disease.

Area of Science:

  • Oncology
  • Urology

Background:

  • Non-metastatic castration-resistant prostate cancer (nmCRPC) presents significant management challenges.
  • Disease heterogeneity and limited clinical data complicate treatment strategies for nmCRPC.

Purpose of the Study:

  • To conduct a systematic review of available treatment options for nmCRPC.
  • To evaluate the role of new generation hormone therapies (NGHT) in nmCRPC management.

Main Methods:

  • Systematic literature review.
  • Analysis of clinical data on apalutamide and enzalutamide.

Main Results:

  • Recent advancements include new generation hormone therapies (NGHT) such as apalutamide and enzalutamide.
  • These therapies offer a new perspective for treatment strategies in nmCRPC.

Conclusions:

  • Apalutamide and enzalutamide represent significant progress in managing nmCRPC.
  • Further research and data are crucial for optimizing nmCRPC treatment protocols.
Keywords:
Castration-resistantHormone therapiesNon-metastaticProstate cancernmCRPC

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