Related Experiment Video

Updated: Feb 4, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.7K

Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction

Marina Loguinova1, Natalia Pinegina1, Valeria Kogan2

  • 1Laboratory of Atherothrombosis, Moscow State University of Medicine and Dentistry, Moscow, Russia.

Thrombosis and Haemostasis
|October 10, 2018
PubMed

Insights

Monocyte-platelet complexes (MPCs) are elevated in acute myocardial infarction (AMI) patients. In AMI, intermediate monocytes form more platelet-rich MPCs, and monocytes from AMI patients aggregate more efficiently with platelets and their extracellular vesicles.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Hematology

Background:

  • Acute myocardial infarction (AMI) involves cellular activation, including platelet aggregation with monocytes to form monocyte-platelet complexes (MPCs).
  • Understanding MPC formation and characteristics is crucial for elucidating AMI pathophysiology.

Purpose of the Study:

  • To analyze in vivo and in vitro monocyte-platelet complexes (MPCs) in acute myocardial infarction (AMI) patients.
  • To investigate monocyte subclass abilities in MPC formation, cellular characteristics, and changes in AMI.

Main Methods:

  • MPCs identified by co-staining for CD41a (platelet) and CD14/CD16 (monocyte) antigens.
  • Platelet activation assessed via phosphatidylserine expression using annexin V.
  • In vitro experiments assessed monocyte aggregation with platelets and platelet-derived extracellular vesicles (EVs).

Main Results:

  • In AMI patients, intermediate monocytes formed more platelet-rich MPCs compared to classical monocytes in controls.
  • MPC numbers were higher in AMI patients and increased with in-hospital complications.
  • Monocytes from AMI patients showed more efficient aggregation with both platelets and platelet EVs in vitro.
  • Evidence suggests some MPCs may involve platelet-derived extracellular vesicles (EVs).

Conclusions:

  • Monocyte-platelet complex patterns differ significantly between AMI patients and healthy controls.
  • Increased MPC formation, particularly by intermediate monocytes and involving platelet EVs, may contribute to AMI pathology.
  • These findings highlight MPCs as a potential factor in acute myocardial infarction progression.

More Related Videos

Acute Myocardial Infarction in Rats07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.6K
Histological Quantification of Chronic Myocardial Infarct in Rats09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.4K

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.5K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.2K
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Complex Numbers01:29

Complex Numbers

The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
310
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.1K