Microbiota and Phage Therapy: Future Challenges in Medicine

Area of Science:

• Microbiology
• Gastroenterology
• Immunology

Background:

• Gut microbiota imbalance is linked to various pathologies.
• Current microbiota manipulation strategies include FMT, pre/probiotics, diet, and phage therapy.
• Bacteriophages (phages) are crucial for microbiome equilibrium but often underestimated.

Purpose of the Study:

• To highlight the therapeutic potential of phages in managing gut microbiota dysbiosis.
• To explore phages as a tool for modulating gut microbiota diversity and function.
• To discuss the role of phages in restoring homeostasis and reducing chronic inflammation.

Main Methods:

• Review of existing literature on phage therapy and microbiota modulation.
• Analysis of phage selection, 'training,' and genetic modification for targeted bacterial infection.
• Exploration of phage-induced changes in microbiota quality and mitochondrial dynamics.

Main Results:

• Phage therapy is effective in reducing pathogenic bacteria and modulating microbiota diversity.
• Genetically modified phages offer potential for treating dysbiosis and associated chronic inflammation.
• Phages can remodel microbiota and mitochondria to restore system equilibrium.

Conclusions:

• Phages are valuable for controlling pathogenic infections and hold future promise for microbiota modulation.
• Phage therapy can rebalance the dynamic between phages and bacteria, adding new functions to bacterial species.
• Rethinking traditional medical strategies to incorporate phage-based interventions is essential for future medicine.